Protein L—More Than Just an Affinity Ligand
نویسندگان
چکیده
In the past 30 years, highly specific drugs, known as antibodies, have conquered biopharmaceutical market. addition to monoclonal antibodies (mAbs), antibody fragments are successfully applied. However, recombinant production faces challenges. Process analytical tools for monitoring and controlling processes scarce time-intensive. downstream process (DSP), affinity ligands established primary most important step, while application of other methods is challenging. The use these would enable a platform technology monitor steps in USP DSP. this review, we highlight current applications (proteins A, G, L) discuss further tools.
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ژورنال
عنوان ژورنال: Processes
سال: 2021
ISSN: ['2227-9717']
DOI: https://doi.org/10.3390/pr9050874